CTE Studies
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DIAGNOSE CTE Research Project
Diagnostics, Imaging, And Genetics Network for the Objective Study and Evaluation (DIAGNOSE) of Chronic Traumatic Encephalopathy (CTE)
This study is looking to develop diagnostic criteria for CTE. Dr. Stern is the contact PI (other PI’s are J. Cummings, E. Reiman, and M. Shenton) of this $16 million, multi-center, multi-disciplinary, 7-year grant to further his initial work on the development of in vivo biomarkers for CTE and clinical diagnostic criteria. This study is funded by the NIH/ NINDS and will begin recruitment in Summer 2016. Former NFL players, former college football players, and “control” participants between the ages of 45 and 74 will be recruited for examinations to be held at one of four locations (Boston, New York, Las Vegas, Scottsdale/Pheonix).
CURRENTLY ENROLLING: Learn how to participate HERE or contact Taylor Platt at diagnose@bu.edu or 617-358-6562
Click HERE to visit the DIAGNOSE CTE Research Project website
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The LEGEND Study
Longitudinal Examination to Gather Evidence of Neurodegenerative Disease
The study focuses on examining the effects of repetitive head impacts (like one may receive playing some organized sports) in living people. Participants complete online questionnaires and talk with a member of our study staff once a year over the phone so we may gather information on concussions, athletic history, medical history, and cognitive functioning. Participants can also choose to provide a saliva sample for genetic analysis. The goal is to track our participants’ progress over time, so we can see who develops problems down the road and who does not.
CURRENTLY ENROLLING: Learn how to participate HERE or contact the LEGEND Study at LEGEND@bu.edu or 617-414-8389
Learn more HERE
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DETECT
Diagnosing and Evaluating Traumatic Encephalopathy using Clinical Tests
THIS STUDY IS COMPLETE
This study was the first research project on CTE ever funded by the National Institutes of Health (NIH), with support from the National Institute of Neurologic Diseases and Stroke (NINDS), the National Institute on Aging (NIA), and the National Institute of Child Health and Human Development (NICHD). The ultimate goal of this study was to develop methods of diagnosing CTE during life through the use of a variety of tests, including MRI scans (such as diffusion tensor imaging), MRS scans (also known as a “virtual biopsy”), blood tests, and measures of proteins in spinal fluid. Participants also underwent neurological, psychiatric, and cognitive assessments, as well as genetic testing.
Click HERE for published journal articles